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dc.contributor.authorKlein, O-
dc.contributor.authorGao, B-
dc.contributor.authorMichael, M-
dc.contributor.authorZielinski, R-
dc.contributor.authorSo, J-
dc.contributor.authorHarris, S.J-
dc.contributor.authorKee, D-
dc.contributor.authorCollins, I.M-
dc.contributor.authorLam, W-S-
dc.contributor.authorLyle, M-
dc.contributor.authorUnderhill, C.R-
dc.contributor.authorBrown, M-
dc.contributor.authorWong, S.F-
dc.contributor.authorPalmer, J.B-
dc.contributor.authorThomas, D-
dc.contributor.authorWilkie, K-
dc.contributor.authorCebon, J-
dc.contributor.authorCarlino, M.S-
dc.date.accessioned2024-09-22T23:14:18Z-
dc.date.available2024-09-22T23:14:18Z-
dc.date.issued2024-09-
dc.identifier.urihttps://repository.southwesthealthcare.com.au/swhealthcarejspui/handle/1/4212-
dc.description.abstractMismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) cancers (ca) are one of the most immunogenic ca. Anti-PD-1 monotherapy using Pembrolizumab has regulatory approval in advanced MSI-H colorectal ca (CRC) and non-CRCs leading to durable responses in a 1/3 of pts. Combined anti-PD-1/CTLA-4 blockade using nivolumab (nivo) and ipilimumab (ipi) has shown superiority to anti-PD-1 monotherapy in other immunogenic ca such as melanoma. MoST-CIRCUIT is the first trial that investigated combined anti-PD-1/CTLA-4 blockade in advanced dMMR/MSI-H non-CRCs.en
dc.subjectCanceren
dc.subjectNivolumaben
dc.subjectIpilimumaben
dc.subjectdMMR/MSI-H noncolorectal cancersen
dc.subjectMoST-CIRCUITen
dc.title998MO Nivolumab and ipilimumab combination treatment in advanced dMMR/MSI-H noncolorectal cancers: Results from the phase II MoST-CIRCUIT studyen
dc.typeConference Paperen
dc.identifier.journaltitleAnnals of Oncologyen
dc.description.conferencenameESMO Congress 2024-
dc.accession.numberhttps://doi.org/10.1016/j.annonc.2024.08.1057en
dc.identifier.urlhttps://www.annalsofoncology.org/article/S0923-7534(24)02576-6/fulltexten
dc.format.startpageS679en
dc.source.volume35en
dc.format.pagesS679 - S680en
dc.identifier.importdoihttps://doi.org/10.1016/j.annonc.2024.08.1057en
dc.identifier.date2024-09-
dc.contributor.swhauthorCollins, Ian M.-
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