Welcome to South West Healthcare
Leaders in healthcare, partners in wellbeing.
Please use this identifier to cite or link to this item:
https://repository.southwesthealthcare.com.au/swhealthcarejspui/handle/1/3870| Journal Title: | Targeting homologous recombination deficiency in uterine leiomyosarcoma |
| Authors: | Collins, Ian M. Dall, Genevieve Vandenberg, Cassandra J. Nesic, Ksenija Ratnayake, Gayanie Zhu, Wenying Vissers, Joseph H. A. Bedo, Justin Penington, Jocelyn Wakefield, Matthew J. Kee, Damien Carmagnac, Amandine Lim, Ratana Shield-Artin, Kristy Milesi, Briony Lobley, Amanda Kyran, Elizabeth L. O'Grady, Emily Tram, Joshua Zhou, Warren Nugawela, Devindee Stewart, Kym Pham Caldwell, Reece Papadopoulos, Lia Ng, Ashley P. Barker, Holly E. Dobrovic, Alexander Fox, Stephen B. McNally, Orla Power, Jeremy D. Meniawy, Tarek Han Tan, Teng Klein, Oliver Barnett, Stephen Olesen, Inger Hamilton, Anne Hofmann, Oliver Grimmond, Sean Papenfuss, Anthony T. Scott, Clare L. |
| SWH Author: | Collins, Ian M. Klein, Oliver |
| Keywords: | Cancer Leiomyosarcoma Uterine Gynaecology uLMS DNA |
| Issue Date: | 4-May-2023 |
| Date Accessioned: | 2023-05-11T23:38:09Z |
| Date Available: | 2023-05-11T23:38:09Z |
| Accession Number: | 112 |
| Url: | https://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02687-0 |
| Description Affiliation: | SouthWest Healthcare, Warrnambool, VIC, 3280, Australia Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia Royal Women’s Hospital, Parkville, VIC, 3052, Australia Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne, Parkville, VIC, 3010, Australia School of Computing and Information Systems, the University of Melbourne, Parkville, VIC, 3010, Australia Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia Austin Health, Heidelberg, VIC, 3084, Australia Australian Rare Cancer Portal, BioGrid Australia, Melbourne Health, Parkville, VIC, 3052, Australia Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, 3010, Australia Royal Melbourne Hospital, Parkville, VIC, 3052, Australia Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC, 3010, Australia Launceston General Hospital, Launceston, TAS, 7250, Australia University of Western Australia, Perth, WA, 6009, Australia SouthWest Healthcare, Warrnambool, VIC, 3280, Australia Faculty of Health, School of Medicine, Deakin University, Warrnambool, VIC, 3280, Australia Western Hospital, Footscray, VIC, 3011, Australia University Hospital Geelong, Geelong, VIC, 3220, Australia |
| Source Volume: | 42 |
| Issue Number: | 112 |
| DOI: | 10.1186/s13046-023-02687-0 |
| Date: | 2023 |
| Abstract: | Uterine leiomyosarcoma (uLMS) is a rare and aggressive gynaecological malignancy, with individuals with advanced uLMS having a five-year survival of < 10%. Mutations in the homologous recombination (HR) DNA repair pathway have been observed in ~ 10% of uLMS cases, with reports of some individuals benefiting from poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) therapy, which targets this DNA repair defect. In this report, we screened individuals with uLMS, accrued nationally, for mutations in the HR repair pathway and explored new approaches to therapeutic targeting. |
| URI: | https://repository.southwesthealthcare.com.au/swhealthcarejspui/handle/1/3870 |
| Journal Title: | Journal of Experimental & Clinical Cancer Research |
| ISSN: | 1756-9966 |
| Type: | Journal Article |
| Appears in Collections: | SWH Staff Publications |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| J Experimental & Clinical Cancer Research - 2023 - Targeting homologous recombination deficiency in uterine leiomyosarcoma.pdf | 9.69 MB | Adobe PDF |  View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.